Articles
2024
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M (2024) Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6.
Nakamura T*, Ito J*, Mourão ASD, Wahida A, Nakagawa K, Mishima E*, Conrad M* (2024) A tangible method to assess native ferroptosis suppressor activity. Cell Rep Methods. 2024 Feb 23:100710. doi: 10.1016/j.crmeth.2024.100710. Online ahead of print. (* equal contribution)
Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M, Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP (2024) 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature. 2024 Feb;626(7998):401-410. doi: 10.1038/s41586-023-06878-9. Epub 2024 Jan 31.
Galy B*, Conrad M*, Muckenthaler M* (2024) Mechanisms controlling cellular and systemic iron homeostasis. Nat Rev Mol Cell Biol. 2024 Feb;25(2):133-155. doi: 10.1038/s41580-023-00648-1. Epub 2023 Oct 2. (* equal contribution)
2023
Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B*, Conrad M* (2023) Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. (* equal contribution)
Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP (2023) LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12.
Mishima E*, Nakamura T*, Zheng J*, Zhang W, Mourão ASD, Sennhenn P, Conrad M (2023) DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. (*equal contribution)
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M (2023) Phase separation of FSP1 promotes ferroptosis. Nature. 619:371-377.
Mishima E, Wahida A, Seibt T, Conrad M (2023) Diverse biological functions of vitamin K: from coagulation to ferroptosis. Nat Metab. 5:924-932.
Mishima E, Conrad M (2023) Nonmetabolic role for CKB in ferroptosis. Nat Cell Biol. 25:633-634.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, et al (2023) Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 30:1097-1154.
Wahida A, Conrad M (2023) Ferroptosis: Under pressure! Curr Biol. 2023 Apr 10;33(7):R269-R272. doi: 10.1016/j.cub.2023.03.009.
Alli AA, Desai D, Elshika A, Conrad M, Proneth B, Clapp W, Atkinson C, Segal M, Searcy LA, Denslow ND, Bolisetty S, Mehrad B, Morel L, Scindia Y (2023) Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis. Clin Immunol. 2023 Mar;248:109213. doi: 10.1016/j.clim.2022.109213. Epub 2022 Dec 22.
2022
Mishima E*, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M*(2022) A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 608:778-783. (* equal contribution)
Farmer LA, Wu Z, Poon JF, Zilka O, Lorenz SM, Huehn S, Proneth B, Conrad M, Pratt DA (2022) Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death. J Am Chem Soc. 144:14706-14721.
Mishima E, Conrad M (2022) Nutritional and Metabolic Control of Ferroptosis. Annu Rev Nutr. 2022 Aug 22;42:275-309. doi:10.1146/annurev-nutr-062320-114541. Epub 2022 Jun 1.
Belaidi AA, Masaldan S, Southon A, Kalinowski P, Acevedo K, Appukuttan AT, Portbury S, Lei P, Agarwal P, Leurgans SE, Schneider J, Conrad M, Bush AI, Ayton S (2022) Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol Psychiatry. 2022 Apr 28. doi: 10.1038/s41380-022-01568-w. Online ahead of print.
Kram H, Prokop G, Haller B, Gempt J, Wu Y, Schmidt-Graf F, Schlegel J, Conrad M, Liesche-Starnecker F(2022) Glioblastoma Relapses Show Increased Markers of Vulnerability to Ferroptosis. Front Oncol. 2022 Apr 21;12:841418. doi: 10.3389/fonc.2022.841418. eCollection 2022.
Günes Günsel G, Conlon TM, Jeridi A, Kim R, Ertüz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar Ö, Konyalilar N, Kanashova T, Rodius S, Ballester-López C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Königshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AÖ (2022) The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun. 2022 Mar 14;13(1):1303. doi: 10.1038/s41467-022-28809-4.
Van Coillie S, Van San E, Goetschalckx I, Wiernicki B, Mukhopadhyay B, Tonnus W, Choi SM, Roelandt R, Dumitrascu C, Lamberts L, Dams G, Weyts W, Huysentruyt J, Hassannia B, Ingold I, Lele S, Meyer E, Berg M, Seurinck R, Saeys Y, Vermeulen A, van Nuijs ALN, Conrad M, Linkermann A, Rajapurkar M, Vandenabeele P, Hoste E, Augustyns K, Vanden Berghe T (2022) Targeting ferroptosis protects against experimental (multi)organ dysfunction and death. Nat Commun. 2022 Feb 24;13(1):1046. doi: 10.1038/s41467-022-28718-6.
Kotschi S, Jung A, Willemsen N, Ofoghi A, Proneth B, Conrad M, Bartelt A (2022) NFE2L1-mediated proteasome function protects from ferroptosis. Mol Metab. 2022 Mar;57:101436. doi: 10.1016/j.molmet.2022.101436. Epub 2022 Jan 6.
Rodriguez R, Schreiber SL, Conrad M (2022) Persister cancer cells: Iron addiction and vulnerability to ferroptosis. Mol Cell. 82:728-740.
Liu H, Forouhar F, Seibt T, Saneto R, Wigby K, Friedman J, Xia X, Shchepinov MS, Ramesh SK, Conrad M, Stockwell BR (2022) Characterization of a patient-derived variant of GPX4 for precision therapy. Nat Chem Biol. 18:91-100.
2021
Fradejas-Villar N, Zhao W, Reuter U, Doengi M, Ingold I, Bohleber, Conrad M, Schweizer U (2021) Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4. Redox Biol. (202 S1). doi.org/10.1016/j.redox.2021.102188.
Kelmanson IV, Shokhina AG, Kotova DA, Pochechuev MS, Ivanova AD, Kostyuk AI, Panova AS, Borodinova AA, Solotenkov MA, Stepanov EA, Raevskii RI, Moshchenko AA, Pak VV, Ermakova YG, van Belle GJC, Tarabykin V, Balaban PM, Fedotov IV, Fedotov AB, Conrad M, Bogeski I, Katschinski DM, Doeppner TR, Bähr M, Zheltikov AM, Bilan DS, Belousov VV (2021) In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model. Redox Biol. 2021 Nov 3;48:102178. doi: 10.1016/j.redox.2021.102178. Online ahead of print.
Zheng H, Jiang L, Tsuduki T, Conrad M, Toyokuni S (2021) Embryonal erythropoiesis and aging exploit ferroptosis. Redox Biol. 2021 Oct 30;48:102175. doi:10.1016/j.redox.2021.102175. Online ahead of print
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B (2021) Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2.
Homma T, Kobayashi S, Conrad M, Konno H, Yokoyama C, Fujii J (2021) Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide. 2021 Jul 27:S1089-8603(21)00076-8. doi: 10.1016/j.niox.2021.07.003. Online ahead of print.
Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A (2021) Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nat Commun. 2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6.
Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M (2021) Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis. 2021 Jul 13;12(7):698. doi: 10.1038/s41419-021-03998-w
Shui S, Zhao Z, Wang H, Conrad M, Liu G (2021) Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway. Redox Biol. 2021 Sep;45:102056. doi: 10.1016/j.redox.2021.102056. Epub 2021 Jun 23.
Truong DJ, Phlairaharn T, Eßwein B, Gruber C, Tümen D, Baligács E, Armbrust N, Vaccaro FL, Lederer EM, Beck EM, Geilenkeuser J, Göppert S, Krumwiede L, Grätz C, Raffl G, Schwarz D, Zirngibl M, Živanić M, Beyer M, Körner JD, Santl T, Evsyukov V, Strauß T, Schwarz SC, Höglinger GU, Heutink P, Doll S, Conrad M, Giesert F, Wurst W, Westmeyer GG (2021) Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol. 23:652-663.
Aldrovandi M, Fedorova M, Conrad M (2021) Juggling with lipids, a game of Russian roulette. Trends Endocrinol Metab. 32:463-473.
Beatty A, Singh T, Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayır H, Kagan VE, Rennefahrt U, Peterson JR (2021) Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. Apr 14;12(1):2244. doi: 10.1038/s41467-021-22471-y.
Kameritsch P, Singer M, Nuernbergk C, Rios N, Reyes AM, Schmidt K, Kirsch J, Schneider H, Müller S, Pogoda K, Cui R, Kirchner T, de Wit C, Lange-Sperandio B, Pohl U, Conrad M, Radi R, Beck H (2021) The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e1921828118. doi: 10.1073/pnas.1921828118.
Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 22:266-282.
Nagakannan P, Islam MI, Conrad M, Eftekharpour E (2021) Cathepsin B is an executioner of ferroptosis. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118928. doi: 10.1016/j.bbamcr.2020.118928. Epub 2020 Dec 17
2020
Zheng J, Conrad M (2020) The Metabolic Underpinnings of Ferroptosis. Cell Metab. 32:920-937.
Aldrovandi M, Conrad M (2020) Ferroptosis: the Good, the Bad and the Ugly. Cell Res. doi:10.1038/s41422-020-00434-0 (2020).
Conrad M, Novikova M (2020) A cozy niche in an iron world. Signal Transduct Target Ther. 2020 Nov 4;5(1):261. doi: 10.1038/s41392-020-00368-4.
Buday K, Conrad M (2020) Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease. Biol Chem. 2020 Oct 22:/j/bchm.ahead-of-print/hsz-2020-0286/hsz-2020-0286.xml. doi: 10.1515/hsz-2020-0286. Online ahead of print.
Conrad M, Lorenz SM, Proneth B (2020) Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases. Trends Mol Med. 2020 Sep 18:S1471-4914(20)30215-X. doi: 10.1016/j.molmed.2020.08.010. Online ahead of print.
Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Friedmann Angeli JP, Proneth B, Conrad M, Okada F, Sato H (2020) Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and dramatically increases survival rates of mice. Int J Cancer. 147:3224-3235.
Jenkins NL, James SA, Salim A, Sumardy F, Speed TP, Conrad M, Richardson DR, Bush AI, McColl G (2020) Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans. Elife. 2020 Jul 21;9:e56580. doi: 10.7554/eLife.56580
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D (2020) Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. J. Hepatol. 73:1347-1359.
Conrad M (2020) NNT in NSCLC: No need to worry? J Exp Med. 2020 Jun 1;217(6). pii: e20200310. doi: 10.1084/jem.20200310.
Conrad M, Proneth B (2020) Selenium: Tracing Another Essential Element of Ferroptotic Cell Death. Cell Chem Biol. 27:409-419.
Venkatesh D, O’Brien NA, Zandkarimi F, Tong DR, Stokes ME, Dunn DE, Kengmana ES, Aron AT, Klein AM, Csuka JM, Moon SH, Conrad M, Chang CJ, Lo DC, D’Alessandro A, Prives C, Stockwell BR (2020) MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. Genes Dev. 34:526-543.
Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF (2020) Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB J. 34:2465-2482.
2001 – 2019
Conrad M, Pratt DA (2019) The chemical basis of ferroptosis. Nat Chem Biol. 15:1137–1147.
Doll S*, Porto Freitas F*, Shah R, Aldrovandi M, Costa da Silva M, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel C, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White A, Sauer M, Sattler7 M Tate ET, Schmitz11, Almut Schulze W, O’Donnell V, Proneth B, Popowicz GM, Pratt DA, Friedmann Angeli JP*, Conrad M* (2019) FSP1 is a Glutathione-Independent Ferroptosis Suppressor. Nature. 575:693-698 (* equal contribution)
Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrabé de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW (2019) Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. 105:937-950.
Friedmann Angeli JP, Krysko DV, Conrad M (2019) Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 19:405-414.
Conrad M, Proneth B (2019) Broken hearts: Iron overload, ferroptosis and cardiomyopathy. Cell Res. 229:263-264.
Seibt TM, Proneth B, Conrad M (2019) Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 133:144-152.
Proneth B, Conrad M (2019) Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 26:14-24.
Anthonymuthu T; Kenny E; Shrivastava I, Tyurina Y, Hier Z, Ting HC, Dar H, Tyurin V, Nesterova A, Amoscato A, Mikulska-Ruminska K, Rosenbaum J, Mao G, Jinming Z, Conrad M, Kellum J, Wenzel S, VanDemark A, Bahar I, Kagan EV, Bayir H (2018) Empowerment of 15-lipoxygenase catalytic competence in selective oxidation of membrane ETE-PE to ferroptotic death signals, HpETE-PE. J Am Chem Soc. 140:17835-17839.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Berghe WV, Vandenabeele P, Berghe TV (2018) Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 128:3341-3355.
Conrad M, Kagan VE, Bayir H, Pagnussat GC, Head B, Traber MG, Stockwell BR (2018) Regulation of lipid peroxidation and ferroptosis in diverse species. Genes Dev. 32:602-619.
Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B (2018) hIAPP forms toxic oligomers in plasma. Chem Commun (Camb). 54:5426-5429.
Muri J, Heer S, Matsushita M, Pohlmeier L, Tortola L, Fuhrer T, Conrad M, Zamboni N, Kisielow J, Kopf M (2018) The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation. Nat Commun. 2018 May 10;9(1):1851. doi: 10.1038/s41467-018-04274-w
Lewerenz J, Ates G, Methner A, Conrad M, Maher P (2018) Oxytosis / Ferroptosis – (Re-)Emerging Roles for Oxidative Stress-Dependent Non-Apoptotic Cell Death in Diseases of the Central Nervous System. Front Neurosci. Apr 20;12:214. doi: 10.3389/fnins.2018.00214. eCollection 2018.
Li C, Deng X, Zhang W, Xie X, Conrad M, Liu Y, Angeli JPF, Lai L (2018) Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 62:266-275.
Ingold I, Conrad M (2018) Selenium and iron, two elemental rivals in the ferroptotic death process. Oncotarget. 9:22241-22242.
Friedmann Angeli JP, Conrad M (2018) Lipoxygenases—Killers against Their Will? ACS Cent. Sci. 4:312-314.
Chen Y, Liu Y, Lan T, Qin W, Zhu Y, Qin K, Gao J, Wang H, Hou X, Chen N, Friedmann Angeli JP, Conrad M, Wang C (2018) Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J Am Chem Soc. 2018 140:4712-4720.
Friedmann Angeli JP, Conrad M (2018) Selenium and GPX4, a vital symbiosis. Free Radic Biol Med. 127:153-159.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25:486-541.
Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, Izumikawa T, Conrad M, Bannai S, Sato H (2018) The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells. Sci Rep. 17:968.
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M (2018) Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 172:409-422.e21.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 171:273-285.
Drefs M, Thomas MN, Guba M, Angele MK, Werner J, Conrad M, Steib CJ, Holdt L, Andrassy J, Khandoga A, Rentsch M (2017) Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-mediated Cell Death after Hepatic Ischemia and Reperfusion. Oxid Med Cell Longev. 2017:8325754. doi: 10.1155/2017/8325754. Epub 2017 Jul 24
Schriever SC, Zimprich A, Pfuhlmann K, Baumann P, Giesert F, Klaus V, Kabra DG, Hafen U, Romanov A, Tschöp MH, Wurst W, Conrad M, Hölter SM, Vogt Weisenhorn D, Pfluger PT (2017) Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. 357:241-254.
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo S, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, Dang PM, De Smet B, Debelec–Butuner B, Dias I, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg V, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem V, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A (2017) European Contribution to the study of ROS: A Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS). Redox Biol. 13:94-162.
Maiorino M, Conrad M, Ursini F (2017) GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues. Antioxid Redox Signal. 2017 May 30. doi: 10.1089/ars.2017.7115. [Epub ahead of print]
Zilka O, Shah R, Li B, Friedmann Angeli JP, Griesser M, Conrad M, Pratt DA (2017) On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 3:232-243.
Angeli JP, Shah R, Pratt DA, Conrad M (2017) Ferroptosis Inhibition: Mechanisms and Opportunities. Trends Pharmacol Sci. 38:489-498.
Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B (2017) The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes. Sci Rep. 7:44041.
Doll S, Conrad M (2017) Iron and ferroptosis: A still ill-defined liaison. IUBMB Life. 69:423-434.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP*, Conrad M* (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 13:91-98. (*equal contribution)
Kagan VE*, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M*, Bayır H* (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 13:81-90. (*corresponding authors)
Kim SE, Zhang L, Ma K, Riegman M, Chen F, Ingold I, Conrad M, Turker MZ, Gao M, Jiang X, Monette S, Pauliah M, Gonen M, Zanzonico P, Quinn T, Wiesner U, Bradbury MS, Overholtzer M. (2016) Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat Nanotechnol. 11:977-985.
Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL*, Conrad M* (2016) Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biol 9:22-31. (*equal contribution)
Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Prabhu KS, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y (2016) Selenoprotein Gene Nomenclature. J Biol Chem. 291:24036-24040.
Kirsch J, Schneider H, Pagel JI, Rehberg M, Singer M, Hellfritsch J, Chillo O, Schubert KM, Qiu J, Pogoda K, Kameritsch P, Uhl B, Pircher J, Deindl E, Müller S, Kirchner T, Pohl U, Conrad M, Beck H. (2016) Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium. Arterioscler Thromb Vasc Biol. 36:1891-9.
Peng X, Giménez-Cassina A, Petrus P, Conrad M, Rydén M, Arnér ES. (2016) Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness. Sci Rep. 6:28080.
Telorack M, Meyer M, Ingold I, Conrad M, Bloch W, Werner S (2016) A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair. PLoS Genet. 12:e1005800.
Conrad M*, Angeli JPF*, Vandenabeele P, Stockwell BR (2016) Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 15:348-66. (*equal contribution)
Gascon S, Murenu E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson S, Schroeder T, Beckers J, Irmler M, Berndt C, Friedmann Angeli JP, Conrad M, Berninger B, Götz M (2016) Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming. Cell Stem Cell. 18:396-409.
Holzerova E, Danhauser K, Haack TB, Kremer LS, Melcher M, Ingold I, Kobayashi S, Terrile C, Wolf P, Schaper J, Mayatepek E, Baertling F, Friedmann Angeli JP, Conrad M, Strom TM, Meitinger T, Holger P, Distelmaier F (2016) Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. Brain. 139:346-54.
Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Angeli JP, Conrad M (2015) Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. J Biol Chem. 290:14668-78.
Labazi , McNeil AK, Kurtz T, Lee TC, Pegg RB, Angeli JPF, Conrad M, McNeil P (2015) The Antioxidant Requirement for Plasma Membrane Repair in Skeletal Muscle. Free Radic Biol Med. 84:246-253.
Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M (2015) T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 212:555-68.
Riemer J, Schwarzländer M, Conrad M, Herrmann JM (2015) Thiol switches in mitochondria: Operation and physiological relevance. Biol Chem. 396:465-82.
Kobayashi S, Sato M, Kasakoshi T, Tsutsui T, Sugimoto M, Osaki M, Okada F, Igarashi K, Hiratake J, Homma T, Conrad M, Fujii J, Soga T, Bannai S, Sato H (2015) Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function. J Biol Chem. 290:8778-88.
Hellfritsch J, Kirsch J, Schneider M, Perisic T, Wortmann M, Frijhoff J, Dagnell M, Fey T, Esposito I, Kölle P, Pogoda K, Angeli JPF, Kliewer I, Kuhlencordt P, Östman A, Pohl U, Conrad M, Beck H (2015) Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis. Antioxid Redox Signal. 22:938-50.
Kagan VE, Tyurina YY, Tyurin V, Mohammadyani D, Angeli JP, Baranov SV, Klein-Seetharaman J, Friedlander RM, Mallampalli RK, Conrad M, Bayir H (2015) Cardiolipin Signaling Mechanisms: Collapse of Asymmetry and Oxidation. Antioxid Redox Signal. 22:1667-80.
Conrad M, Ingold I, Buday K, Kobayashi S, Angeli JPF (2015) ROS, thiols and thiol-regulating systems in male gametogenesis. Biochim Biophys Acta. 1850:1566-1574.
Conrad M, Angeli JPF (2015) Glutathione peroxidase 4 (Gpx4) and ferroptosis: what’s so special about it? Mol Cell Oncol. 2:e995047(12) Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Angeli JP, Conrad M (2015) Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. J Biol Chem. 290:14668-78.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O’Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 16:1180-91.
Wirth EK, Bharathi BS, Hatfield D, Conrad M, Brielmeier M, Schweizer U (2014) Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons. Biol Trace Elem Res. 158:203-210.
Lewerenz J, Baxter P, Kassubek R, Albrecht P, Liefferinge JV, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P (2014) Phosphoinositide 3-Kinases Upregulate System xc- via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 - A Pathway Active in Glioblastomas and Epilepsy. Antioxid Redox Signal. 20:2907-22.
Peng X, Mandal PK, Kaminskyy VO, Lindqvist A, Conrad M, Arnér ES (2014) Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2. Cell Death Dis. 5:e1235.
Huang, H, Koelle P, Fendler M, Schröttle A, Czihal M, Hoffmann U, Conrad M, Kuhlencordt PJ (2014) Induction of Inducible Nitric Oxide Synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration. Atherosclerosis. 235:213-22.
Dagnell M, Frijhoff J, Pader I, Augsten M, Boivin B, Xu J, Mandal PK, Tonks NK, Hellberg C, Conrad M, Arnér ES, Östman A (2013) Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling. Proc Natl Acad Sci U S A. 110:13398-403.
Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, Vegi N, Kölle P, Kuhlencordt P, Walch A, Pohl U, Bornkamm GW, Conrad M*, Beck H* (2013) Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice. Circ Res. 113:408-17. (* corresponding authors)
Patterson AD, Carlson AB, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL (2013) Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity. Chem Res Toxicol. 26:1088-96.
Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M (2013) Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7. Biochim Biophys Acta. 1830:3846-57.
Sengupta A, Lichti UF, Carlson BA, Cataisson C, Ryscavage AO, Mikulec C, Conrad M, Fischer SM, Hatfield DL, Yuspa SH (2013) Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2. J Invest Dermatol. 133:1731-41.
Conrad M, Schick J, Angeli JP (2013) Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice. Neurochem Int. 62:738-49.
Noblanc A, Peltier M, Damon-Soubeyrand C, Kerchkove N, Chabory E, Vernet P, Saez F, Cadet R, Janny L, Pons-Rejraji H, Conrad M, Drevet JR, Kocer A (2012) Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice. PLoS One. 2012;7(6):e38565.
Azimzadeh O, Scherthan H, Yentrapalli R, Barjaktarovic Z, Ueffing M, Conrad M, Neff F, Calzada-Wack J, Aubele M, Buske C, Atkinson MJ, Hauck SM, Tapio S (2012) Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation. J Proteomics. 75:2384-2395.
Puglisi R, Maccari I, Pipolo S, Conrad M, Mangia F, Boitani C (2012) The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization. J Cell Physiol. 227:1420-1427.
Conrad M, Sato H (2012) The oxidative stress-inducible cystine/glutamate antiporter, system xc-: cystine supplier and beyond. Amino Acids. 42:231-246.
Horstkotte J, Perisic T, Schneider M, Lange P, Schroeder M, Kiermayer C, Hinkel R, Ziegler T, Mandal PK, David R, Schulz S, Schmitt S, Widder J, Sinowatz F, Becker BF, Bauersachs J, Naebauer M, Franz WM, Jeremias I, Brielmeier M, Zischka H, Conrad M*, Kupatt C* (2011) Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection. Circulation. 124:2892-2902. (*equal contribution)
Carlson BA, Yoo MH, Conrad M, Gladyshev VN, Hatfield DL, Park JM (2011) Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol. 49:311-316.
Azimzadeh O, Scherthan H, Sarioglu H, Barjaktarovic Z, Conrad M, Vogt A, Calzada-Wack J, Neff F, Aubele M, Buske C, Atkinson MJ, Tapio S (2011) Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics. 11:3299-3311.
Rehklau K, Gurniak CB, Conrad M, Friauf, E Ott M, Rust MB (2011) ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signalling. Cell Death Differ. 19:958-67.
Noblanc A, Kocer A, Chabory E, Vernet P, Saez F, Cadet R, Conrad M, Drevet JR (2011) Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on Mammalian male fertilizing ability. J Androl. 32:641-650.
Mannes AM, Seiler A, Bosello V, Maiorino M, Conrad M (2011) Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme. FASEB J. 25:2135-2144.
Sibbing D, Pfeufer A, Perisic T, Mannes AM, Fritz-Wolf K, Unwin S, Sinner MF, Gieger C, Gloeckner CJ, Wichmann HE, Kremmer E, Schäfer Z, Walch A, Hinterseer M, Näbauer M, Kääb S, Kastrati A, Schömig A, Meitinger T, Bornkamm GW*, Conrad M*, von Beckerath N* (2011) Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy. Eur Heart J. 32:1121-1133. (* equal contribution)
Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H, De Bundel D, Vermoesen K, Bannai S, Smolders I, Conrad M, Plesnila N, Sato H, Michotte Y (2011) Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB J. 25:1359-1369.
Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 18:282-292.
Mandal PK, Schneider M, Kölle P, Kuhlencordt P, Förster H, Beck H, Bornkamm GW, Conrad M (2010) Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation. Cancer Res. 70:9505-9514.
Conrad M, Sandin A, Förster H, Seiler A, Frijhoff J, Dagnell M, Bornkamm GW, Rådmark O, Hooft van Huijsduijnen R, Aspenström P, Böhmer F, Ostman A (2010) 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 107:15774-15779.
Mandal PK, Seiler A, Perisic T, Kölle P, Banjac Canak A, Förster H, Weiss N, Kremmer E, Lieberman MW, Bannai S, Kuhlencordt P, Sato H, Bornkamm GW, Conrad M (2010) System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency. J Biol Chem. 285:22244-22253.
Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M. (2010) Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Exp Cell Res. 316:1662-80.
Schneider M, Wortmann M, Mandal PK, Arpornchayanon W, Jannasch K, Alves F, Strieth S, Conrad M, Beck H (2010) Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia. 12:254-263.
Wirth EK, Conrad M, Winterer J, Wozny C, Carlson BA, Roth S, Schmitz D, Bornkamm GW, Coppola V, Tessarollo L, Schomburg L, Köhrle J, Hatfield DL, Schweizer U (2010) Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J. 24:844-852.
Conrad M, Schweizer U (2010) Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies. Antiox Redox Signal. 12:851-865.
González Carvajal B, Mack B, Conrad M, Gires O. (2009) EpCAM is a marker of murine embryonic stem cells. Stem Cells. 27:1782-1791.
Conrad M (2009) Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4. Biochim Biophys Acta. 1790:1575-1585.
Schneider M, Förster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumüller C, Deutsch MJ, Walch A, Hrabé de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, Conrad M (2009) Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J. 23:3233-3242.
Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8:237-248.
Soerensen J, Jakupoglu C, Beck H, Förster H, Schmidt J, Schmahl W, Schweizer U, Conrad M, Brielmeier M (2008) The role of thioredoxin reductases in brain development. PloS ONE. 3, e1813.
Banjac A, Perisic T, Sato H, Bannai S, Seiler A, Weiss N, Kölle P, Tschoep K, Issels RD, Daniel PT, Conrad M*, Bornkamm GW* (2008) The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to apoptosis. Oncogene. 27:1618-1628. (*equal contribution)
Geisberger R, Kiermayer C, Homig C, Conrad M, Schmidt J, Zimber-Strobl U, Brielmeier M (2007) Conditional knockout of thioredoxin reductase 2 in CD4- and CD19 Cre mice does not impair B and T helper cell development and function. Biol Chem. 388:1083-1090.
Conrad M, Schneider M, Seiler A, Bornkamm GW (2007) The physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals. Biol Chem. 388:1019-1025.
Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M (2006) Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis. 45:11-16.
Schneider M, Vogt-Weissenhorn D, Bornkamm GW, Brielmeier M, Conrad M (2006) Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase. Gene Expr Patterns. 6:489-494.
Chapman RD, Conrad M, Eick D (2005) Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation. Mol Cell Biol. 25:7665-7674.
Conrad M, Moreno SG, Sinowatz F, Ursini F, Kölle S, Roveri A, Brielmeier M, Wurst W, Maiorino M, Bornkamm GW (2005) The nuclear form of PHGPx is a protein thiol peroxidase contributing to sperm chromatin stability. Mol Cell Biol. 25:7637-7644.
Jakupoglu C, Przemeck GKH, Schneider M, Moreno SG, Mayr N, Hatzopoulos AK, Hrabé de Angelis M, Wurst W, Bornkamm GW, Brielmeier M, Conrad M (2005) Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol. 25:1980-1988.
Conrad M*, Jakupoglu C*, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M (2004) Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 24:9414-23. (*equal contribution)
Conrad M, Brielmeier M, Wurst W, Bornkamm GW (2003) Optimized vector for conditional gene targeting in mouse embryonic stem cells. Biotechniques. 34, 1136-1138: 1140.
Moreno SG, Laux G, Brielmeier M, Bornkamm GW, Conrad M (2003) Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx). Biol Chem. 384:635-643.
Pfeifer H, Conrad M, Roethlein D, Kyriakopoulos A, Brielmeier M, Bornkamm GW, Behne D (2001) Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. FASEB J. 15:1236-1238.
Brielmeier M, Bechet JM, Suppmann S, Conrad M, Laux G, Bornkamm GW (2001) Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells. Biofactors. 14:179-190.
Book Chapters / Miscellaneous
Seibt T, Wahida A, Mishima E, Conrad M (2022) Den „Eisen-Tod“ verhindern – Bedeutung der antioxidativen Vitamine und der Vitamin-K-Familie. Deutsche Apotheker Zeitung. 162. Jahrgang, 27.10.2022, Nr. 43
Conrad M, Costa da Silva M (2020) Ferroptosis: Physiological and pathophysiological aspects. In: Oxidative Stress: Eustress and Distress (Sies, H., ed.), Academic Press, San Diego, pp.149-166 ISBN 9780128186060.
Lorenz S, Conrad M (2019) Ferroptose: Tod durch Eisenabhängige Lipidperoxidation. BIOspektrum 25 (6), 614-616
Ingold I, Conrad M (2018) Oxidative stress, Selenium redox systems including GPX / TXNRD families. In: Molecular and Integrative Toxicology – Selenium, Michalke, Springer, New York, pages 111-134
Friedmann Angeli JP, Kagan VE, Conrad M (2018) Thiols, Glutathione, GPx4, and Lipid Metabolism at the Crossroads of Cell Death and Survival. Glutathione, First Edition L. Flohé. CRC Press, Boca Raton.
Conrad M, Friedmann Angeli, JP (2018) 10.13 – Glutathione Peroxidases A2 – McQueen, Charlene A. In Comprehensive Toxicology (Third Edition) (Oxford: Elsevier).
Friedmann Angeli JP, Proneth P, Conrad M (2016) Glutathione peroxidase 4 (Gpx4) and ferroptosis. Selenium : Its Molecular Biology and Role in Human Health, Fourth Edition D.L. Hatfield, U. Schweizer, P. Tsuji, V.N. Gladyshev,4th ed, Springer, New York.
Conrad M, Schweizer U (2016) Mouse models that target individual selenoproteins. Selenium : Its Molecular Biology and Role in Human Health, Fourth Edition D.L. Hatfield, U. Schweizer, P. Tsuji, V.N. Gladyshev,4th ed, Springer, New York.
Conrad M (2012) Mouse models for glutathione peroxidase 4 (GPx4) Selenium : Its Molecular Biology and Role in Human Health, Third Edition D.L. Hatfield, M. J. Berry, V.N. Gladyshev,3rd ed, Springer, New York.
Conrad M, Brielmeier M, Bornkamm GW (2006) Mitochondrial and Cytosolic Thioredoxin Reductase Knockout Mice. Selenium : Its Molecular Biology and Role in Human Health, Second Edition D.L. Hatfield, M. J. Berry, V.N. Gladyshev, ed, Springer, New York