Conrad Laboratory

A research group at Helmholtz Zentrum München, Neuherberg, Germany.
Biomedical research for redox-regulated life and death decisions.
Ferroptosis in degenerative disease and cancer.

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News

Perspective article on ferroptosis in cancer published in Nature Reviews Cancer

In this Perspective article we discuss how metabolic reprogramming in certain tumor entities may contribute to an acquired sensitivity to ferroptosis, thus leaving a potential vulnerability for the efficient treatment of therapy-resistant tumors. As such, we provide an overview of the known mechanisms that regulate sensitivity to ferroptosis in cancer cells and how the modulation of metabolic pathways controlling ferroptosis might reshape the tumor niche, leading to an immunosuppressive microenvironment ultimately promoting tumor expansion (Further reading: José Pedro Friedmann Angeli, Dmitri V Krysko, Marcus Conrad (2019) Ferroptosis at the Crossroads of Cancer-Acquired Drug Resistance and Immune Evasion. Nat Rev Cancer 19, 405-414).

FSP1 is a novel, glutathione-independent ferroptosis suppressor

Using a genetic suppressor screen in cells lacking the key ferroptosis regulator glutathione peroxidase 4 (GPX4), we now report in Nature the discovery of ferroptosis suppressor protein-1 (FSP1; erroneously annotated as apoptosis-inducing factor, mitochondrion-associated 2, AIFM2) as a novel ferroptosis regulator. The underlying mechanism by which FSP1 robustly protects from ferroptosis is that it regenerates extramitochondrial ubiquinone using electrons from NADH and NADPH thereby preventing detrimental lipid peroxidation. Since FSP1 is widely expressed in a number of tumor cell entities, pharmacological targeting of FSP1 may hold the great potential to combat difficult to treat cancers (Doll et al., Nature 2019)(see also “Identification of a ferroptosis suppressor protein allows for new anticancer treatment approach”)

Review article on ferroptosis published in Nature Reviews Molecular Cell Biology

In our most recent Review article, we provide a critical appraisal of our current understanding of the molecular facets of ferroptosis and highlight early relevant discoveries that paved the way on how we perceive ferroptosis as of today. We focus on key metabolic and signaling pathways that directly impact on the cells’ sensitivity toward ferroptosis and provide an updated practical guideline of Do's and Don'ts in ferroptosis research in order to avoid wrong conclusions based on the inappropriate use of pharmacological and genetic tools and model systems (Further reading: Xuejun Jiang, Brent R. Stockwell, Marcus Conrad (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol https://doi.org/10.1038/s41580-020-00324-8).

About Dr. Conrad

Dr. Marcus Conrad

Dr. Marcus Conrad

  • Head of the Conrad Laboratoy
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Publications

Publications

For an updated list of peer-reviewed publications and book chapters by the Conrad Laboratory see.

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Research

Research

The Conrad laboratory investigates the molecular underpinnings about life and death decisions made by cells in normal tissue homeostasis and in disease. While early cell loss and tissue dysfunction causes acute and chronic degenerative diseases such as ischemia/reperfusion injury and neurodegeneration, aberrant killing of premalignant cells is a known factor in tumor development. The main research focus of the Conrad laboratory involves how perturbed cell metabolism, aberrant redox homeostasis and endoplasmic reticulum stress impact on cell death.

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Lab Members

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