since 05/2012 RESEARCH GROUP LEADER DRUG DISCOVERY
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

  • Development of a chemical genetics drug discovery program

2010 – 2012 HEAD of TRANSGENIC CORE UNIT
German Research Center for Neurodegenerative Diseases (DZNE), Munich, Germany
2009 – 2010 LABORATORY HEAD
Bayer-Schering Pharma AG, Berlin, Germany

  • Global Drug Discovery – Transgenic and Specialized in vivo Pharmacology in Target Identification and Biomarker Research in Oncology

2005 – 2009 RESEARCH GROUP LEADER
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Munich, Germany

  • Dissecting the mechanisms of oxidative stress-induced cell death signaling using conditional knockout mouse and cell models

GUEST RESEARCHER
at Yamagata University, Tsuruoka, Japan (03-05/2007)

SENIOR RESEARCHER
at Karolinska Institute, Department of Oncology – Pathology Stockholm, Sweden (2005 – 2006) (Prof. A. Östman)

  • Lipid hydroperoxides as novel regulators of receptor tyrosine kinase signaling

2004 – 2005 PROJECT LEADER
Department of Comparative Medicine, Helmholtz Zentrum München, Munich, Germany
2001 – 2004 POST-DOC
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Munich, Germany


1998 – 2001 PhD STUDENT
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Munich, Germany, and Ludwig-Maximilians-University Munich, Germany
Thesis: “Generation of transgenic mice deficient for the selenoproteins mitochondrial thioredoxin reductase and phospholipid hydroperoxide glutathione peroxidase (PHGPx) and characterization of a sperm nuclei-specific form of PHGPx

1997 – 1998 MASTER of SCIENCE
Biology at University of Konstanz, Germany
Thesis: „Thymidylat-Synthase als Modellenzym für molekulare Adaptation an hochosmolare Umwelt
1992 – 1997 STUDIES of BIOLOGY
University of Konstanz, Germany



2007 “European Molecular Biology Laboratory”
2005 “Japan Society for the Promotion of Science”


November 2014 WO 2016075137 A1: Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
July 2013 WO 2015007730 A1: Spiroquinoxaline derivatives as inhibitors of non-apoptotic regulated cell-death
February 2001 WO 2002072626 A2: Novel form of the PHGPx protein as a diagnostic marker for male infertility